A116 LOSS OF RESPONSE TO VEDOLIZUMAB MAINTENANCE THERAPY IN CROHN`S DISEASE
نویسندگان
چکیده
منابع مشابه
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients with active disease. In the trial of induction therapy, 374 patients (cohort 1) received vedolizumab (at a dose of 300 mg) or placebo intravenousl...
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P a t i e n t s 335 of 573 patients (median age 35 y, 61% women) who had Crohn disease ≥ 3 months in duration; had a Crohn’s Disease Activity Index (CDAI) score between 220 and 400; and responded to a single infusion of infliximab, 5 mg/kg, within 2 weeks. Response was defined as a decrease in CDAI score ≥ 70 points from baseline and a reduction in the total score ≥ 25%. Exclusion criteria incl...
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Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) characterized by inflammation of the mucosal layer of the colon. The resulting disease includes episodes of recurrent rectal bleeding, increased stool frequency and urgency, abdominal cramps and pain, and systemic symptoms (such as fever, anemia, and weight loss).1 Historical studies have estimated that approximately half of ...
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We here report a case of a young man who presented to his general practitioner with diarrhea. Inflammatory bowel disease was suspected and a colonoscopy showed aphthous lesions suggestive of Crohns' disease but biopsies revealed eggs of Enterobius vermicularis. When treated for this parasite, his symptoms were alleviated and a followup colonoscopy revealed a normal colon and distal ileum. Enter...
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BACKGROUND Metabolic processes in adipose tissue are dysregulated in obese subjects and, in response to weight loss, either normalize or change in favor of weight regain. OBJECTIVE To determine changes in adipocyte glucose and fatty acid metabolism in relation to changes in adipocyte size during weight loss and maintenance. METHODS Twenty-eight healthy subjects (12 males), age 20-50 y, and ...
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ژورنال
عنوان ژورنال: Journal of the Canadian Association of Gastroenterology
سال: 2018
ISSN: 2515-2084,2515-2092
DOI: 10.1093/jcag/gwy009.116